Design and validation of a dosimetric comparison scheme tailored for ultra-high dose-rate electron beams to support multicenter FLASH preclinical studies.

Details

Serval ID
serval:BIB_FC59EAAA1608
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Design and validation of a dosimetric comparison scheme tailored for ultra-high dose-rate electron beams to support multicenter FLASH preclinical studies.
Journal
Radiotherapy and oncology
Author(s)
Gonçalves Jorge P., Melemenidis S., Grilj V., Buchillier T., Manjappa R., Viswanathan V., Gondré M., Vozenin M.C., Germond J.F., Bochud F., Moeckli R., Limoli C., Skinner L., Joshua No H., Fred Wu Y., Surucu M., Yu A.S., Lau B., Wang J., Schüler E., Bush K., Graves E.E., Maxim P.G., Loo B.W., Bailat C.
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
We describe a multicenter cross validation of ultra-high dose rate (UHDR) (>= 40 Gy/s) irradiation in order to bring a dosimetric consensus in absorbed dose to water. UHDR refers to dose rates over 100-1000 times those of conventional clinical beams. UHDR irradiations have been a topic of intense investigation as they have been reported to induce the FLASH effect in which normal tissues exhibit reduced toxicity relative to conventional dose rates. The need to establish optimal beam parameters capable of achieving the in vivo FLASH effect has become paramount. It is therefore necessary to validate and replicate dosimetry across multiple sites conducting UHDR studies with distinct beam configurations and experimental set-ups.
Using a custom cuboid phantom with a cylindrical cavity (5 mm diameter by 10.4 mm length) designed to contain three type of dosimeters (thermoluminescent dosimeters (TLDs), alanine pellets, and Gafchromic films), irradiations were conducted at expected doses of 7.5 to 16 Gy delivered at UHDR or conventional dose rates using various electron beams at the Radiation Oncology Departments of the CHUV in Lausanne, Switzerland and Stanford University, CA.
Data obtained between replicate experiments for all dosimeters were in excellent agreement (+/- 3 %). In general, films and TLDs were in closer agreement with each other, while alanine provided the closest match between the expected and measured dose, with certain caveats related to absolute reference dose.
In conclusion, successful cross-validation of different electron beams operating under different energies and configurations lays the foundation for establishing dosimetric consensus for UHDR irradiation studies, and, if widely implemented, decrease uncertainty between different sites investigating the mechanistic basis of the FLASH effect.
Keywords
FLASH, TLD, UHDR, alanine, comparison, dosimetry, film, radiometrology, ultra-high dose-rate
Pubmed
Create date
05/09/2022 8:47
Last modification date
02/11/2022 6:41
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