Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

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Serval ID
serval:BIB_FBB52AEAFE2C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
Journal
Biochemistry
Author(s)
Haefliger J.A., Tschopp J., Nardelli D., Wahli W., Kocher H.P., Tosi M., Stanley K.K.
ISSN
0006-2960 (Print)
ISSN-L
0006-2960
Publication state
Published
Issued date
06/1987
Volume
26
Number
12
Pages
3551-3556
Language
english
Abstract
The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.
Keywords
Amino Acid Sequence, Base Sequence, Cloning, Molecular, Complement C8/genetics, Complement C9/genetics, DNA/analysis, Humans, Liver/metabolism, Macromolecular Substances, Sequence Homology, Nucleic Acid
OAI-PMH
oai:serval.unil.ch:BIB_FBB52AEAFE2C
DOI
10.1021/bi00386a045
Pubmed
3651397
Web of science
A1987H856800045
Create date
24/01/2008 16:18
Last modification date
20/08/2019 17:26
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