Amoebal pathogens as emerging causal agents of pneumonia.

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Serval ID
serval:BIB_FB7AFE6B97C1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Amoebal pathogens as emerging causal agents of pneumonia.
Journal
Fems Microbiology Reviews
Author(s)
Lamoth Frederic, Greub Gilbert
ISSN
1574-6976[electronic], 0168-6445[linking]
Publication state
Published
Issued date
2009
Volume
34
Number
3
Pages
260-280
Language
english
Abstract
Despite using modern microbiological diagnostic approaches, the aetiological agents of pneumonia remain unidentified in about 50% of cases. Some bacteria that grow poorly or not at all in axenic media used in routine clinical bacteriology laboratory but which can develop inside amoebae may be the agents of these lower respiratory tract infections (RTIs) of unexplained aetiology. Such amoebae-resisting bacteria, which coevolved with amoebae to resist their microbicidal machinery, may have developed virulence traits that help them survive within human macrophages, i.e. the first line of innate immune defence in the lung. We review here the current evidence for the emerging pathogenic role of various amoebae-resisting microorganisms as agents of RTIs in humans. Specifically, we discuss the emerging pathogenic roles of Legionella-like amoebal pathogens, novel Chlamydiae (Parachlamydia acanthamoebae, Simkania negevensis), waterborne mycobacteria and Bradyrhizobiaceae (Bosea and Afipia spp.).
Keywords
Free-Living Amoebae, Amoebae-Resisting Bacteria, Legionella, Chlamydia-Like Bacteria, Mycobacteria, Pneumonia, Community-Acquired Pneumonia, Chlamydia-Like Microorganism, Legionella-Maceachernii Pneumonia, Cat-Scratch Disease, Amebas-Resisting Bacteria, Water-Treatment-Plant, Free-Living Amebas, of-the-Literature, Mycobacterium-Kansasii Infection, Ventilator-Associated Pneumonia
Pubmed
Web of science
Open Access
Yes
Create date
22/04/2010 8:55
Last modification date
25/09/2019 7:11
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