Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.

Details

Serval ID
serval:BIB_FB03C7981490
Type
Article: article from journal or magazin.
Collection
Publications
Title
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.
Journal
Journal of Clinical Investigation
Author(s)
Fajas L., Annicotte J.S., Miard S., Sarruf D., Watanabe M., Auwerx J.
ISSN
0021-9738 (Print)
ISSN-L
0021-9738
Publication state
Published
Issued date
2004
Volume
113
Number
9
Pages
1288-1295
Language
english
Abstract
We evaluated the effects of E2F1 on glucose homeostasis using E2F1(-/-) mice. E2F1(-/-) mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth. Furthermore, these animals have dysfunctional beta cells, linked to impaired PDX-1 activity. Because of the disproportionate small pancreas and dysfunctional islets, E2F1(-/-) mice secrete insufficient amounts of insulin in response to a glucose load, resulting in glucose intolerance. Despite this glucose intolerance, E2F1(-/-) mice do not develop overt diabetes mellitus because they have insulin hypersensitivity, which is secondary to a diminished adipose tissue mass and altered adipocytokine levels, which compensates for the defect in insulin secretion. These data demonstrate that factors controlling cell proliferation, such as E2F1, determine pancreatic growth and function, subsequently affecting metabolic homeostasis.
Keywords
Adaptor Proteins, Signal Transducing, Adipocytes/cytology, Adipocytes/metabolism, Animals, Apoptosis, Blood Glucose/metabolism, Carrier Proteins/metabolism, Cell Division, Gene Expression Regulation, Glucose/metabolism, Glucose Intolerance, Homeodomain Proteins, Homeostasis, Insulin/blood, Insulin/secretion, Islets of Langerhans/cytology, Islets of Langerhans/metabolism, Leptin/blood, Male, Mice, Mice, Knockout, Muscle, Smooth/cytology, Muscle, Smooth/metabolism, Pancreas/cytology, Pancreas/growth & development, RNA-Binding Proteins, Time Factors, Trans-Activators/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
07/03/2013 16:04
Last modification date
20/08/2019 16:26
Usage data