Hyperphosphatémie et insuffisance rénale transitoire après chimiothérapie d'une leucémie lymphoblastique aiguë [Hyperphosphatemia and transient renal insufficiency following chemotherapy of acute lymphoblastic leukemia]

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Final published version
Serval ID
serval:BIB_FAD2A73C5303
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Hyperphosphatémie et insuffisance rénale transitoire après chimiothérapie d'une leucémie lymphoblastique aiguë [Hyperphosphatemia and transient renal insufficiency following chemotherapy of acute lymphoblastic leukemia]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Aubert J.D., Claeys M., Zwahlen A., Wauters J.P.
ISSN
0036-7672
Publication state
Published
Issued date
1988
Peer-reviewed
Oui
Volume
118
Number
51
Pages
1953-1956
Language
french
Notes
Publication types: Case Reports ; English Abstract ; Journal Article
Abstract
Acute renal failure during treatment of lymphoblastic malignancies is usually due to drug toxicity or acute uric nephropathy. Observations were recently reported where extreme hyperphosphatemia may represent another pathophysiological mechanism. We describe 2 cases, in 36- and 77-year-old women, with acute lymphoblastic leukemia. Acute renal failure was observed 2 days after cytotoxic treatment. Maximal blood creatinine values were 860 and 550 mumol/l respectively, and for phosphate 6.3 and 7.5 mmol/l. With oral phosphate binders, and after four peritoneal exchanges for the second patient, renal function gradually returned to normal values within 4 weeks. Tumor lysis syndrome with associated hyperphosphatemia is described exclusively in lymphoblastic malignancies and renal failure is probably a consequence of intratubular calcium phosphate precipitation. In this situation prophylactic administration of phosphate binders and attentive monitoring of phosphatemia are necessary.
Keywords
Adult, Aged, Aluminum Hydroxide, Antineoplastic Combined Chemotherapy Protocols, Creatinine, Female, Humans, Kidney Failure, Acute, Phosphates, Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pubmed
Web of science
Create date
21/01/2008 13:54
Last modification date
20/08/2019 17:26
Usage data