Neural correlates of motor recovery after stroke: a longitudinal fMRI study.

Details

Serval ID
serval:BIB_FA98404C9CCD
Type
Article: article from journal or magazin.
Collection
Publications
Title
Neural correlates of motor recovery after stroke: a longitudinal fMRI study.
Journal
Brain
Author(s)
Ward N.S., Brown M.M., Thompson A.J., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Publication state
Published
Issued date
2003
Volume
126
Number
Pt 11
Pages
2476-2496
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Recovery of motor function after stroke may occur over weeks or months and is often attributed to cerebral reorganization. We have investigated the longitudinal relationship between recovery after stroke and task-related brain activation during a motor task as measured using functional MRI (fMRI). Eight first-ever stroke patients presenting with hemiparesis resulting from cerebral infarction sparing the primary motor cortex, and four control subjects were recruited. Subjects were scanned on a number of occasions whilst performing an isometric dynamic visually paced hand grip task. Recovery in the patient group was assessed using a battery of outcome measures at each time point. Task-related brain activations decreased over sessions as a function of recovery in a number of primary and non-primary motor regions in all patients, but no session effects were seen in the controls. Furthermore, consistent decreases across sessions correlating with recovery were seen across the whole patient group independent of rate of recovery or initial severity, in primary motor cortex, premotor and prefrontal cortex, supplementary motor areas, cingulate sulcus, temporal lobe, striate cortex, cerebellum, thalamus and basal ganglia. Although recovery-related increases were seen in different brain regions in four patients, there were no consistent effects across the group. These results further our understanding of the recovery process by demonstrating for the first time a clear temporal relationship between recovery and task-related activation of the motor system after stroke.
Keywords
Adult, Aged, Brain/pathology, Brain/physiopathology, Cerebral Infarction/pathology, Cerebral Infarction/physiopathology, Female, Hand Strength, Humans, Image Processing, Computer-Assisted/methods, Longitudinal Studies, Magnetic Resonance Imaging/methods, Male, Middle Aged, Motor Cortex/pathology, Motor Cortex/physiopathology, Motor Skills, Neuronal Plasticity, Psychomotor Performance, Recovery of Function
Pubmed
Web of science
Open Access
Yes
Create date
11/09/2011 18:40
Last modification date
20/08/2019 16:26
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