Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands
Details
Serval ID
serval:BIB_FA49D05AD2A9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands
Journal
Behavior Genetics
ISSN
0001-8244
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
30
Number
6
Pages
497
Language
english
Notes
SAPHIRID:67392
Abstract
Two mouse lines were selectively bred according to their sensitivity (BS line) or resistance (BR line) to seizures induced by a single i.p. injection of methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodiazepine site. Our aim was to characterize both lines' sensitivities to various physiological effects of other ligands of the GABA(A) receptor. We measured diazepam-induced anxiolysis with the elevated plus-maze test, diazepam-induced sedation by recording the vigilance states, and picrotoxin- and pentylenetetrazol-induced seizures after i.p. injections. Results presented here show that the differential sensitivities of BS and BR lines to beta-CCM can be extended to diazepam, picrotoxin, and pentylenetetrazol, suggesting a genetic selection of a general sensitivity and resistance to several ligands of the GABA(A) receptor.
Pubmed
Web of science
Create date
11/03/2008 14:07
Last modification date
20/08/2019 16:25