Metabolic Control of CD8<sup>+</sup> T Cell Fate Decisions and Antitumor Immunity.

Details

Serval ID
serval:BIB_FA3C9C58E397
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Metabolic Control of CD8<sup>+</sup> T Cell Fate Decisions and Antitumor Immunity.
Journal
Trends in molecular medicine
Author(s)
Zhang L., Romero P.
ISSN
1471-499X (Electronic)
ISSN-L
1471-4914
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
24
Number
1
Pages
30-48
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
CD8 <sup>+</sup> T cells are central players in controlling infections and cancer. Longevity, functionality, and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy. Tumor-infiltrating CD8 <sup>+</sup> T cells undergo metabolic 'exhaustion' in the nutrient- and oxygen-deprived tumor microenvironment (TME). Thus, reprograming CD8 <sup>+</sup> T cell metabolism may provide important therapeutic strategies for cancer treatment. Indeed, the adoptive transfer of memory CD8 <sup>+</sup> T cells with sustained metabolic fitness may yield better antitumor protection in both mouse models and the clinic. Here, we discuss recent progress on how cellular metabolism is linked to CD8 <sup>+</sup> T cell fate decisions and on how metabolic intermediates can impact gene expression via modulation of the epigenome. We examine the feasibility of developing potential strategies to improve antitumor immunity through the modulation of T cell metabolic activity.
Keywords
Animals, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Differentiation, Epigenesis, Genetic, Humans, Immunotherapy, Adoptive/methods, Neoplasms/genetics, Neoplasms/immunology, Neoplasms/metabolism, Neoplasms/therapy, Organelle Biogenesis, Protein Kinases/immunology, Protein Kinases/metabolism, TOR Serine-Threonine Kinases/immunology, TOR Serine-Threonine Kinases/metabolism, Tumor Microenvironment
Pubmed
Web of science
Create date
10/01/2018 12:19
Last modification date
20/08/2019 17:25
Usage data