Metabolic Control of CD8<sup>+</sup> T Cell Fate Decisions and Antitumor Immunity.

Détails

ID Serval
serval:BIB_FA3C9C58E397
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Metabolic Control of CD8<sup>+</sup> T Cell Fate Decisions and Antitumor Immunity.
Périodique
Trends in molecular medicine
Auteur(s)
Zhang L., Romero P.
ISSN
1471-499X (Electronic)
ISSN-L
1471-4914
Statut éditorial
Publié
Date de publication
01/2018
Peer-reviewed
Oui
Volume
24
Numéro
1
Pages
30-48
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
CD8 <sup>+</sup> T cells are central players in controlling infections and cancer. Longevity, functionality, and metabolic fitness are critical determinants of T cell efficacy in cancer immunotherapy. Tumor-infiltrating CD8 <sup>+</sup> T cells undergo metabolic 'exhaustion' in the nutrient- and oxygen-deprived tumor microenvironment (TME). Thus, reprograming CD8 <sup>+</sup> T cell metabolism may provide important therapeutic strategies for cancer treatment. Indeed, the adoptive transfer of memory CD8 <sup>+</sup> T cells with sustained metabolic fitness may yield better antitumor protection in both mouse models and the clinic. Here, we discuss recent progress on how cellular metabolism is linked to CD8 <sup>+</sup> T cell fate decisions and on how metabolic intermediates can impact gene expression via modulation of the epigenome. We examine the feasibility of developing potential strategies to improve antitumor immunity through the modulation of T cell metabolic activity.
Mots-clé
Animals, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/metabolism, Cell Differentiation, Epigenesis, Genetic, Humans, Immunotherapy, Adoptive/methods, Neoplasms/genetics, Neoplasms/immunology, Neoplasms/metabolism, Neoplasms/therapy, Organelle Biogenesis, Protein Kinases/immunology, Protein Kinases/metabolism, TOR Serine-Threonine Kinases/immunology, TOR Serine-Threonine Kinases/metabolism, Tumor Microenvironment
Pubmed
Web of science
Création de la notice
10/01/2018 11:19
Dernière modification de la notice
20/08/2019 16:25
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