The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins.

Details

Serval ID
serval:BIB_F9DA82EBAC80
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins.
Journal
Biomaterials
Author(s)
Longchamp A., Alonso F., Dubuis C., Allagnat F., Berard X., Meda P., Saucy F., Corpataux J.M., Déglise S., Haefliger J.A.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
35
Number
9
Pages
2588-2599
Language
english
Notes
Publication types: Journal Article
Abstract
The saphenous vein is the conduit of choice in bypass graft procedures. Haemodynamic factors play a major role in the development of intimal hyperplasia (IH), and subsequent bypass failure. To evaluate the potential protective effect of external reinforcement on such a failure, we developed an ex vivo model for the perfusion of segments of human saphenous veins under arterial shear stress. In veins submitted to pulsatile high pressure (mean pressure at 100 mmHg) for 3 or 7 days, the use of an external macroporous polyester mesh 1) prevented the dilatation of the vessel, 2) decreased the development of IH, 3) reduced the apoptosis of smooth muscle cells, and the subsequent fibrosis of the media layer, 4) prevented the remodelling of extracellular matrix through the up-regulation of matrix metalloproteinases (MMP-2, MMP-9) and plasminogen activator type I. The data show that, in an experimental ex vivo setting, an external scaffold decreases IH and maintains the integrity of veins exposed to arterial pressure, via increase in shear stress and decrease wall tension, that likely contribute to trigger selective molecular and cellular changes.
Pubmed
Web of science
Create date
06/04/2014 15:36
Last modification date
20/08/2019 16:25
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