Intraoperative radiotherapy in the multimodality approach to colorectal cancer.

Details

Serval ID
serval:BIB_F8DDCD7D6582
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Intraoperative radiotherapy in the multimodality approach to colorectal cancer.
Journal
Surgical Oncology Clinics of North America
Author(s)
Hahnloser D., Haddock M.G., Nelson H.
ISSN
1055-3207 (Print)
ISSN-L
1055-3207
Publication state
Published
Issued date
2003
Volume
12
Number
4
Pages
993-1013
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
The addition of intraoperative radiotherapy (IORT) to the multimodality approach for the treatment of locally advanced and locally recurrent colorectal cancer seems to result in improvements in local control and long-term survival. Local control and survival are most likely in patients in whom a gross total resection is accomplished. Peripheral nerve is the dose-limiting structure for patients treated with IORT. Further improvements in local control require the addition of dose modifiers during external beam radiotherapy or IORT. Distant relapse remains problematic, and effective systemic therapy is necessary to significantly improve long-term survival.
Keywords
Colectomy/methods, Colonic Neoplasms/pathology, Colonic Neoplasms/radiotherapy, Combined Modality Therapy, Humans, Intraoperative Period, Neoplasm Recurrence, Local, Neoplasm Staging, Neoplasm, Residual, Palliative Care/methods, Radiation Tolerance, Radiotherapy, Adjuvant/methods, Rectal Neoplasms/pathology, Rectal Neoplasms/radiotherapy
Pubmed
Create date
06/10/2014 8:56
Last modification date
20/08/2019 16:24
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