Inflammation in gout: mechanisms and therapeutic targets.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_F8C4ACBA5649
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Inflammation in gout: mechanisms and therapeutic targets.
Journal
Nature Reviews. Rheumatology
Author(s)
So A.K., Martinon F.
ISSN
1759-4804 (Electronic)
ISSN-L
1759-4790
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
13
Number
11
Pages
639-647
Language
english
Abstract
The acute symptoms of gout are triggered by the inflammatory response to monosodium urate crystals, mediated principally by macrophages and neutrophils. Innate immune pathways are of key importance in the pathogenesis of gout, in particular the activation of the NLRP3 inflammasome, which leads to the release of IL-1β and other pro-inflammatory cytokines. The orchestration of this pro-inflammatory cascade involves multiple intracellular and extracellular receptors and enzymes interacting with environmental influences that modulate the inflammatory state. Furthermore, the resolution of inflammation in gout is becoming better understood. This Review highlights recent advances in our understanding of both positive and negative regulatory pathways, as well as the genetic and environmental factors that modulate the inflammatory response. Some of these pathways can be manipulated and present novel therapeutic opportunities for the treatment of acute gout attacks.
Keywords
Cytokines/metabolism, Gout/immunology, Gout/metabolism, Gout/therapy, Humans, Immunity, Innate, Immunosuppression/methods, Inflammasomes/metabolism, Inflammation/immunology, Inflammation/metabolism, Macrophages/immunology, Macrophages/metabolism, Neutrophils/immunology, Neutrophils/metabolism
Pubmed
Web of science
Funding(s)
Swiss National Science Foundation / Projects / 310030173152
Create date
12/10/2017 9:56
Last modification date
29/04/2020 6:20
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