Molar pregnancy with a coexistent fetus after intracytoplasmic sperm injection. A case report

Details

Serval ID
serval:BIB_F665D9537C50
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Molar pregnancy with a coexistent fetus after intracytoplasmic sperm injection. A case report
Journal
Journal of Reproductive Medicine
Author(s)
Petignat  P., Senn  A., Hohlfeld  P., Blant  S. A., Laurini  R., Germond  M.
ISSN
0024-7758 (Print)
Publication state
Published
Issued date
03/2001
Volume
46
Number
3
Pages
270-4
Notes
Case Reports
Journal Article
Twin Study --- Old month value: Mar
Abstract
BACKGROUND: Normal fertilization is usually considered to have occurred when two pronculei (2PN) and two polar bodies are observed. Exceptions are the single pronucleated zygote resulting from asynchronous pronuclei. CASE: A 29-year-old woman entered a program of intracytoplasmic sperm injection and embryo transfer because of her husband's oligoasthenoteratozoospermia. Two cleavage-stage embryos (four blastomeres, grade 1 and 2) were obtained from one fertilized oocyte containing distinct 2PN and the other a single pronucleus (1PN). At 15 weeks' gestation the patient developed severe preeclampsia requiring termination of the pregnancy. Histopathologic examination and DNA ploidy by image analysis were consistent with a twin pregnancy combining a complete hydatidiform mole and normal pregnancy. CONCLUSION: We hypothesize that this 1PN was at the origin of the hydatidiform mole. This case highlights the danger of transferring an embryo having 1PN.
Keywords
Abortion, Therapeutic Adult Anemia, Hemolytic/complications Embryo/*pathology Female Humans Hydatidiform Mole/complications/*etiology Photomicrography Pre-Eclampsia/complications/therapy Pregnancy *Pregnancy, Multiple *Sperm Injections, Intracytoplasmic Twins *Zygote Intrafallopian Transfer
Pubmed
Web of science
Create date
25/01/2008 11:11
Last modification date
20/08/2019 16:22
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