Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_F66233AA5A88
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells
Journal
Journal of Medicinal Chemistry
Author(s)
Hanessian S., Zhan L., Bovey R., Saavedra O. M., Juillerat-Jeanneret L.
ISSN
0022-2623 (Print)
Publication state
Published
Issued date
2003
Volume
46
Number
17
Pages
3600-3611
Language
english
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't
Abstract
The effects of functionalized aryl beta-D-glycopyranosides (glycomers) on the proliferation, survival, and apoptosis of human glioblastoma cells in culture were evaluated as a way to control tumor progression. The results showed that inhibition of growth and/or induction of apoptosis can be achieved by these molecules in human glioblastoma cells. Inhibition of DNA synthesis precedes induction of apoptosis and growth inhibition. The substituents at C-1, C-2, C-3,C-4, and C-6 on the pyranosidic scaffold are important to modulate the action and the efficacy of these molecules. Human fibroblasts and brain-derived endothelial cells were less sensitive to glycomers than tumor cells. Thus, functionalized aryl beta-D-glycopyranosides represent a new class of molecules potentially able to control the progression of brain tumors
Keywords
Apoptosis/Brain Neoplasms/Pathology/Cell Division/drug effects/Cell Line/Cerebral Cortex/cytology/Endothelium/Fibroblasts/Glioblastoma/Glucosides/chemical synthesis/chemistry/pharmacology/Humans/Tumor Cells,Cultured
Pubmed
Web of science
Create date
29/01/2008 19:33
Last modification date
14/07/2020 6:21
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