Article: article from journal or magazin.
Functionalized glycomers as growth inhibitors and inducers of apoptosis in human glioblastoma cells
Journal of Medicinal Chemistry
PT - Journal Article PT - Research Support, Non-U.S. Gov't
The effects of functionalized aryl beta-D-glycopyranosides (glycomers) on the proliferation, survival, and apoptosis of human glioblastoma cells in culture were evaluated as a way to control tumor progression. The results showed that inhibition of growth and/or induction of apoptosis can be achieved by these molecules in human glioblastoma cells. Inhibition of DNA synthesis precedes induction of apoptosis and growth inhibition. The substituents at C-1, C-2, C-3,C-4, and C-6 on the pyranosidic scaffold are important to modulate the action and the efficacy of these molecules. Human fibroblasts and brain-derived endothelial cells were less sensitive to glycomers than tumor cells. Thus, functionalized aryl beta-D-glycopyranosides represent a new class of molecules potentially able to control the progression of brain tumors
Apoptosis/Brain Neoplasms/Pathology/Cell Division/drug effects/Cell Line/Cerebral Cortex/cytology/Endothelium/Fibroblasts/Glioblastoma/Glucosides/chemical synthesis/chemistry/pharmacology/Humans/Tumor Cells,Cultured
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