Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.

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State: Public
Version: Final published version
Serval ID
serval:BIB_F64AEA348D4B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Alarm pheromone and kairomone detection via bitter taste receptors in the mouse Grueneberg ganglion.
Journal
BMC biology
Author(s)
Moine F., Brechbühl J., Nenniger Tosato M., Beaumann M., Broillet M.C.
ISSN
1741-7007 (Electronic)
ISSN-L
1741-7007
Publication state
Published
Issued date
18/01/2018
Peer-reviewed
Oui
Volume
16
Number
1
Pages
12
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The mouse Grueneberg ganglion (GG) is an olfactory subsystem specialized in the detection of volatile heterocyclic compounds signalling danger. The signalling pathways transducing the danger signals are only beginning to be characterized.
Screening chemical libraries for compounds structurally resembling the already-identified GG ligands, we found a new category of chemicals previously identified as bitter tastants that initiated fear-related behaviours in mice depending on their volatility and evoked neuronal responses in mouse GG neurons. Screening for the expression of signalling receptors of these compounds in the mouse GG yielded transcripts of the taste receptors Tas2r115, Tas2r131, Tas2r143 and their associated G protein α-gustducin (Gnat3). We were further able to confirm their expression at the protein level. Challenging these three G protein-coupled receptors in a heterologous system with the known GG ligands, we identified TAS2R143 as a chemical danger receptor transducing both alarm pheromone and predator-derived kairomone signals.
These results demonstrate that similar molecular elements might be used by the GG and by the taste system to detect chemical danger signals present in the environment.
Keywords
Animals, Cats, Cell Line, Female, Ganglia, Autonomic/chemistry, Ganglia, Autonomic/metabolism, HEK293 Cells, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pheromones/administration & dosage, Smell/drug effects, Smell/physiology, Taste/drug effects, Taste/physiology, Taste Buds/chemistry, Taste Buds/drug effects, Taste Buds/metabolism, Alarm pheromone, Danger detection, Grueneberg ganglion, Olfaction, Predator scents, TAS2Rs
Pubmed
Web of science
Open Access
Yes
Create date
27/01/2018 14:11
Last modification date
17/09/2020 9:24
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