Prise en charge du syndrome des ­anticorps antiphospholipides chez l’adulte [Management of the antiphospholipid syndrome in adults]

Details

Serval ID
serval:BIB_F55407187560
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Prise en charge du syndrome des ­anticorps antiphospholipides chez l’adulte [Management of the antiphospholipid syndrome in adults]
Journal
Revue medicale suisse
Author(s)
Doms J., Horisberger A., Ribi C.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
08/04/2020
Peer-reviewed
Oui
Volume
16
Number
689
Pages
670-674
Language
french
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The antiphospholipid syndrome (APS) is a complex autoimmune -disease characterized by the expression of antiphospholipid -antibodies (APL) and a variety of clinical presentation. The latest classification defines APS by the occurrence of vascular thrombosis and/or typical obstetrical morbidity together with persistently -detectable APL at least 12 weeks apart. The latest recommendation proposes a risk profile based on the type and titer of APL detected, in order to guide the intensity of prophylactic measures. Based on current knowledge, novel oral anticoagulants should not be used in APS, particularly in patients with a high-risk APL profile or arterial thrombosis. Beyond the mere aspect of anticoagulant treatment, immunomodulatory approaches to the APS such as hydroxychloroquine are under investigation.
Keywords
Adult, Antibodies, Antiphospholipid/blood, Anticoagulants/therapeutic use, Antiphospholipid Syndrome/blood, Antiphospholipid Syndrome/complications, Antiphospholipid Syndrome/drug therapy, Female, Humans, Hydroxychloroquine/therapeutic use, Knowledge, Pregnancy, Pregnancy Complications/blood, Pregnancy Complications/drug therapy, Risk Factors, Thrombosis/blood, Thrombosis/drug therapy, Thrombosis/etiology
Pubmed
Create date
25/04/2020 21:45
Last modification date
03/07/2020 6:26
Usage data