Multiple functions of Notch signaling in self-renewing organs and cancer

Details

Serval ID
serval:BIB_F4023301891A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multiple functions of Notch signaling in self-renewing organs and cancer
Journal
FEBS Letters
Author(s)
Wilson  A., Radtke  F.
ISSN
0014-5793 (Print)
Publication state
Published
Issued date
05/2006
Volume
580
Number
12
Pages
2860-8
Notes
Journal Article
Review --- Old month value: May 22
Abstract
In recent years a substantial body of evidence has accumulated to support the notion that signaling pathways known to be important during embryonic development play important roles in regulating self-renewing tissues. Moreover, the same pathways are often deregulated during tumorigenesis due to mutations of key elements of these pathways. The Notch signaling cascade meets all of the above-mentioned criteria. We discuss here the pleiotropic roles of the Notch signaling pathway in three different self-renewing organs (intestine, hematopoietic system and skin) and how its deregulation is involved in tumorigenesis.
Keywords
Animals Cell Differentiation Hematopoiesis Humans Intestines/cytology Neoplasms/*metabolism/pathology Receptors, Notch/*metabolism *Signal Transduction
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:39
Last modification date
20/08/2019 16:20
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