Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.

Scherrer, A.U.; Yang, W.L.; Kouyos, R.D.; Böni, J.; Yerly, S.; Klimkait, T.; Aubert, V.; Cavassini, M.; Battegay, M.; Hauser, C.; Calmy, A.; Schmid, P.; Bernasconi, E.; Günthard, H.F.

doi:10.1093/infdis/jiw165

Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.

Details

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Serval ID

serval:BIB_F3F1DBACE436

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.

Journal

The Journal of infectious diseases

Author(s)

Scherrer A.U., Yang W.L., Kouyos R.D., Böni J., Yerly S., Klimkait T., Aubert V., Cavassini M., Battegay M., Hauser C., Calmy A., Schmid P., Bernasconi E., Günthard H.F.

Working group(s)

Swiss HIV Cohort Study

Contributor(s)

Aubert V., Battegay M., Bernasconi E., Böni J., Braun D.L., Bucher H.C., Burton-Jeangros C., Calmy A., Cavassini M., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner K., Müller N., Nadal D., Nicca D., Pantaleo G., Rauch A., Regenass S., Rudin C., Schöni-Affolter F., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Vernazza P., Weber R., Yerly S.

ISSN

1537-6613 (Electronic)

ISSN-L

0022-1899

Publication state

Published

Issued date

01/08/2016

Peer-reviewed

Oui

Volume

214

Number

Pages

399-402

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.

Keywords

Anti-HIV Agents/pharmacology, Cohort Studies, Disease Transmission, Infectious, Drug Resistance, Viral, Drug Utilization, HIV/drug effects, HIV/genetics, HIV/isolation & purification, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Infections/transmission, HIV Infections/virology, HIV Integrase/genetics, HIV Integrase Inhibitors/therapeutic use, Humans, Prevalence, Switzerland/epidemiology, HIV-1 drug resistance, integrase, population viral load, prevalence, transmission of drug resistance

OAI-PMH

oai:serval.unil.ch:BIB_F3F1DBACE436

DOI

10.1093/infdis/jiw165

Pubmed

27130429

Web of science

000383267100009

Open Access

Yes

Create date

11/12/2017 12:49