Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.

Details

Serval ID
serval:BIB_F3F1DBACE436
Type
Article: article from journal or magazin.
Collection
Publications
Title
Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.
Journal
The Journal of infectious diseases
Author(s)
Scherrer A.U., Yang W.L., Kouyos R.D., Böni J., Yerly S., Klimkait T., Aubert V., Cavassini M., Battegay M., Hauser C., Calmy A., Schmid P., Bernasconi E., Günthard H.F.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Aubert V., Battegay M., Bernasconi E., Böni J., Braun D.L., Bucher H.C., Burton-Jeangros C., Calmy A., Cavassini M., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner K., Müller N., Nadal D., Nicca D., Pantaleo G., Rauch A., Regenass S., Rudin C., Schöni-Affolter F., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Publication state
Published
Issued date
01/08/2016
Peer-reviewed
Oui
Volume
214
Number
3
Pages
399-402
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.

Keywords
Anti-HIV Agents/pharmacology, Cohort Studies, Disease Transmission, Infectious, Drug Resistance, Viral, Drug Utilization, HIV/drug effects, HIV/genetics, HIV/isolation & purification, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Infections/transmission, HIV Infections/virology, HIV Integrase/genetics, HIV Integrase Inhibitors/therapeutic use, Humans, Prevalence, Switzerland/epidemiology, HIV-1 drug resistance, integrase, population viral load, prevalence, transmission of drug resistance
Pubmed
Web of science
Open Access
Yes
Create date
11/12/2017 12:49
Last modification date
20/08/2019 17:20
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