Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.

Détails

ID Serval
serval:BIB_F3F1DBACE436
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study.
Périodique
The Journal of infectious diseases
Auteur(s)
Scherrer A.U., Yang W.L., Kouyos R.D., Böni J., Yerly S., Klimkait T., Aubert V., Cavassini M., Battegay M., Hauser C., Calmy A., Schmid P., Bernasconi E., Günthard H.F.
Collaborateur(s)
Swiss HIV Cohort Study
Contributeur(s)
Aubert V., Battegay M., Bernasconi E., Böni J., Braun D.L., Bucher H.C., Burton-Jeangros C., Calmy A., Cavassini M., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner K., Müller N., Nadal D., Nicca D., Pantaleo G., Rauch A., Regenass S., Rudin C., Schöni-Affolter F., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
01/08/2016
Peer-reviewed
Oui
Volume
214
Numéro
3
Pages
399-402
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.

Mots-clé
Anti-HIV Agents/pharmacology, Cohort Studies, Disease Transmission, Infectious, Drug Resistance, Viral, Drug Utilization, HIV/drug effects, HIV/genetics, HIV/isolation & purification, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Infections/transmission, HIV Infections/virology, HIV Integrase/genetics, HIV Integrase Inhibitors/therapeutic use, Humans, Prevalence, Switzerland/epidemiology, HIV-1 drug resistance, integrase, population viral load, prevalence, transmission of drug resistance
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/12/2017 12:49
Dernière modification de la notice
20/08/2019 17:20
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