Molecular epidemiology of Pseudomonas aeruginosa in intensive care units over a 10-year period (1998-2007).
Details
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_F3A85FA074BF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Molecular epidemiology of Pseudomonas aeruginosa in intensive care units over a 10-year period (1998-2007).
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Publication state
Published
Issued date
01/2011
Peer-reviewed
Oui
Volume
17
Number
1
Pages
57-62
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Pseudomonas aeruginosa is one of the leading nosocomial pathogens in intensive care units (ICUs). The source of this microorganism can be either endogenous or exogenous. The proportion of cases as a result of transmission is still debated, and its elucidation is important for implementing appropriate control measures. To understand the relative importance of exogenous vs. endogenous sources of P. aeruginosa, molecular typing was performed on all available P. aeruginosa isolated from ICU clinical and environmental specimens in 1998, 2000, 2003, 2004 and 2007. Patient samples were classified according to their P. aeruginosa genotypes into three categories: (A) identical to isolate from faucet; (B) identical to at least one other patient sample and not found in faucet; and (C) unique genotype. Cases in categories A and B were considered as possibly exogenous, and cases in category C as possibly endogenous. A mean of 34 cases per 1000 admissions per year were found to be colonized or infected by P. aeruginosa. Higher levels of faucet contamination were correlated with a higher number of cases in category A. The number of cases in category B varied from 1.9 to 20 cases per 1000 admissions. This number exceeded 10/1000 admissions on three occasions and was correlated with an outbreak on one occasion. The number of cases considered as endogenous (category C) was stable and independent of the number of cases in categories A and B. The present study shows that repeated molecular typing can help identify variations in the epidemiology of P. aeruginosa in ICU patients and guide infection control measures.
Keywords
Cross Infection/epidemiology, Cross Infection/transmission, Environmental Microbiology, Genotype, Humans, Intensive Care Units/statistics & numerical data, Molecular Epidemiology, Molecular Typing, Prevalence, Pseudomonas Infections/epidemiology, Pseudomonas Infections/transmission, Pseudomonas aeruginosa/genetics
Pubmed
Open Access
Yes
Create date
20/01/2011 16:00
Last modification date
20/08/2019 17:20