A preclinical model for identifying rats at risk of alcohol use disorder.

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State: Public
Version: Final published version
Serval ID
serval:BIB_F3999F21A3C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A preclinical model for identifying rats at risk of alcohol use disorder.
Journal
Scientific reports
Author(s)
Jadhav K.S., Magistretti P.J., Halfon O., Augsburger M., Boutrel B.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
25/08/2017
Peer-reviewed
Oui
Volume
7
Number
1
Pages
9454
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains of highest importance. We propose here to adapt current methodologies for identifying rats at risk of losing control over alcohol intake by modeling diagnostic criteria for AUD: inability to abstain during a signaled period of reward unavailability, increased motivation assessed in a progressive effortful task and persistent alcohol intake despite aversive foot shocks. Factor analysis showed that these three addiction criteria loaded on one underlying construct indicating that they represent a latent construct of addiction trait. Further, not only vulnerable rats displayed higher ethanol consumption, and higher preference for ethanol over sweetened solutions, but they also exhibited pre-existing higher anxiety as compared to resilient rats. In conclusion, the present preclinical model confirms that development of an addiction trait not only requires prolonged exposure to alcohol, but also depends on endophenotype like anxiety that predispose a minority of individuals to lose control over alcohol consumption.
Keywords
Alcohol Drinking/adverse effects, Alcoholism/physiopathology, Alcoholism/psychology, Animals, Anxiety/physiopathology, Anxiety/psychology, Behavior, Animal, Conditioning, Operant, Disease Models, Animal, Ethanol/adverse effects, Humans, Male, Rats, Rats, Wistar, Reward, Risk, Self Administration
Pubmed
Web of science
Open Access
Yes
Create date
01/09/2017 8:48
Last modification date
20/08/2019 17:20
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