HIV-1 latent reservoir: size matters.

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Version: Final published version
Serval ID
serval:BIB_F2B9E7CAEBE7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
HIV-1 latent reservoir: size matters.
Journal
Future virology
Author(s)
Hodel F., Patxot M., Snäkä T., Ciuffi A.
ISSN
1746-0794 (Print)
ISSN-L
1746-0794
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
11
Number
12
Pages
785-794
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
More than 35 million people remain infected with HIV-1. Upon antiretroviral therapy cessation, HIV-1-positive individuals systematically fail to achieve sustained virological remission, revealing the presence of a reservoir. This reservoir takes into account anatomical sanctuaries where HIV-1 continues to replicate, and latently infected cells also known as the latent reservoir (LR). A better understanding of the nature and features of the LR and its quantification are crucial to evaluate the efficiency of therapeutic strategies aiming at purging HIV-1. Culture- and PCR-based assays have already been implemented to measure the LR, and new assays are continuously being developed. In this review, we will discuss these methods highlighting the difficulties to accurately measure the LR, one main obstacle in curing HIV-1.

Keywords
DNA, HIV-1, RNA, assays, latent reservoir, quantification, size
Pubmed
Web of science
Create date
08/08/2017 11:17
Last modification date
20/08/2019 16:19
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