Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition.

Details

Serval ID
serval:BIB_F283634981A1
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition.
Journal
Chimia
Author(s)
Gerber-Lemaire S., Juillerat-Jeanneret L.
ISSN
0009-4293[print], 0009-4293[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
64
Number
9
Pages
634-639
Language
english
Abstract
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi alpha-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of alpha-mannosidases II able to induce antiproliferative effects in human cancer cells.
Pubmed
Web of science
Create date
13/12/2010 10:23
Last modification date
20/08/2019 16:19
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