Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition.

Détails

ID Serval
serval:BIB_F283634981A1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition.
Périodique
Chimia
Auteur(s)
Gerber-Lemaire S., Juillerat-Jeanneret L.
ISSN
0009-4293[print], 0009-4293[linking]
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
64
Numéro
9
Pages
634-639
Langue
anglais
Résumé
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi alpha-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of alpha-mannosidases II able to induce antiproliferative effects in human cancer cells.
Pubmed
Web of science
Création de la notice
13/12/2010 11:23
Dernière modification de la notice
03/03/2018 22:40
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