Atypical coordination of cortical oscillations in response to speech in autism.

Details

Ressource 1Download: 25870556_BIB_F2610D613F61.pdf (1684.47 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_F2610D613F61
Type
Article: article from journal or magazin.
Collection
Publications
Title
Atypical coordination of cortical oscillations in response to speech in autism.
Journal
Frontiers in Human Neuroscience
Author(s)
Jochaut D., Lehongre K., Saitovitch A., Devauchelle A.D., Olasagasti I., Chabane N., Zilbovicius M., Giraud A.L.
ISSN
1662-5161 (Electronic)
ISSN-L
1662-5161
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
9
Pages
171
Language
english
Notes
Publication types: Journal Article Publication Status: epublish
Abstract
Subjects with autism often show language difficulties, but it is unclear how they relate to neurophysiological anomalies of cortical speech processing. We used combined EEG and fMRI in 13 subjects with autism and 13 control participants and show that in autism, gamma and theta cortical activity do not engage synergistically in response to speech. Theta activity in left auditory cortex fails to track speech modulations, and to down-regulate gamma oscillations in the group with autism. This deficit predicts the severity of both verbal impairment and autism symptoms in the affected sample. Finally, we found that oscillation-based connectivity between auditory and other language cortices is altered in autism. These results suggest that the verbal disorder in autism could be associated with an altered balance of slow and fast auditory oscillations, and that this anomaly could compromise the mapping between sensory input and higher-level cognitive representations.
Pubmed
Web of science
Open Access
Yes
Create date
01/05/2015 18:07
Last modification date
20/08/2019 17:19
Usage data