Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis.

Details

Serval ID
serval:BIB_F213C2D7C2EC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis.
Journal
Research and practice in thrombosis and haemostasis
Author(s)
Longchamp A., Longchamp J., Manzocchi-Besson S., Whiting L., Haller C., Jeanneret S., Godio M., Garcia Martinez J.J., Bonjour T., Caillat M., Maitre G., Thaler J.M., Pantet R., Donner V., Dumoulin A., Emonet S., Greub G., Friolet R., Robert-Ebadi H., Righini M., Sanchez B., Delaloye J.
ISSN
2475-0379 (Electronic)
ISSN-L
2475-0379
Publication state
Published
Issued date
07/2020
Peer-reviewed
Oui
Volume
4
Number
5
Pages
842-847
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronavirus disease 2019 (COVID-19), has caused more than 3.9 million cases worldwide. Currently, there is great interest to assess venous thrombosis prevalence, diagnosis, prevention, and management in patients with COVID-19.
To determine the prevalence of venous thromboembolism (VTE) in critically ill patients with COVID-19, using lower limbs venous ultrasonography screening.
Beginning March 8, we enrolled 25 patients who were admitted to the intensive care unit (ICU) with confirmed SARS-CoV-2 infections. The presence of lower extremity deep vein thrombosis (DVT) was systematically assessed by ultrasonography between day 5 and 10 after admission. The data reported here are those available up to May 9, 2020.
The mean (± standard deviation) age of the patients was 68 ± 11 years, and 64% were men. No patients had a history of VTE. During the ICU stay, 8 patients (32%) had a VTE; 6 (24%) a proximal DVT, and 5 (20%) a pulmonary embolism. The rate of symptomatic VTE was 24%, while 8% of patients had screen-detected DVT. Only those patients with a documented VTE received a therapeutic anticoagulant regimen. As of May 9, 2020, 5 patients had died (20%), 2 remained in the ICU (8%), and 18 were discharged (72%).
In critically ill patients with SARS-CoV-2 infections, DVT screening at days 5-10 of admission yielded a 32% prevalence of VTE. Seventy-five percent of events occurred before screening. Earlier screening might be effective in optimizing care in ICU patients with COVID-19.
Keywords
COVID‐19, SARS virus, pulmonary embolism, ultrasonography, venous thrombosis
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / PZ00P3-185927
Create date
24/07/2020 13:12
Last modification date
08/03/2021 6:26
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