Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.

Details

Ressource 1Download: viruses-10-00178.pdf (286.35 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_F1F98CD58878
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.
Journal
Viruses
Author(s)
Rohde C., Resch G., Pirnay J.P., Blasdel B.G., Debarbieux L., Gelman D., Górski A., Hazan R., Huys I., Kakabadze E., Łobocka M., Maestri A., Almeida GMF, Makalatia K., Malik D.J., Mašlaňová I., Merabishvili M., Pantucek R., Rose T., Štveráková D., Van Raemdonck H., Verbeken G., Chanishvili N.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
10
Number
4
Pages
1-15
Language
english
Abstract
Phage therapy is increasingly put forward as a "new" potential tool in the fight against antibiotic resistant infections. During the "Centennial Celebration of Bacteriophage Research" conference in Tbilisi, Georgia on 26-29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as policy makers, officials of the competent authorities for medicines, phage researchers and phage producers, and members of the pharmaceutical industry. This brief also points out potential avenues for future phage therapy research and development as it specifically addresses those overarching questions that currently call for attention whenever phages go into purification processes for application.
Keywords
Bacteriophage, adaptation, phage therapy, production, prophage, regulation, resistance
Pubmed
Web of science
Open Access
Yes
Create date
14/04/2018 11:23
Last modification date
20/08/2019 17:19
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