Surveillance of HIV type 1 drug resistance among naive patients from Venezuela.

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State: Serval
Version: author
Serval ID
serval:BIB_F1CE32A29002
Type
Article: article from journal or magazin.
Collection
Publications
Title
Surveillance of HIV type 1 drug resistance among naive patients from Venezuela.
Journal
AIDS Research and Human Retroviruses
Author(s)
Castillo J., Comegna M., Quijada W., Jauvin V., Pinson P., Masquelier B., Fleury H., Castro E.
ISSN
1931-8405 ([electronic])
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
25
Number
12
Pages
1329-1333
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We have studied 65 HIV-1-infected untreated patients recruited in Caracas, Venezuela with TCD4 counts > or =350/microl. The reverse transcriptase and protease sequences of the virus were sequenced, aligned with reference HIV-1 group M strains, and analyzed for drug resistance mutations. Most of the viruses were subtype B genotype in both the protease and RT genomic regions. Five of the 62 virus isolates successfully amplified showed evidence of recombination between protease and RT, with their protease region being non-B while their RT region was derived from subtype B. Four strains were found bearing resistance mutations either to NRTIs, NNRTIs, or PIs. The prevalence of HIV-1 isolates bearing resistance mutations was therefore above the 5% threshold of WHO.
Pubmed
Web of science
Open Access
Yes
Create date
26/01/2010 16:42
Last modification date
09/05/2019 3:20
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