K-ras and p53 mutations in hereditary non-polyposis colorectal cancers

Details

Serval ID
serval:BIB_F1A5200B2BB3
Type
Article: article from journal or magazin.
Collection
Publications
Title
K-ras and p53 mutations in hereditary non-polyposis colorectal cancers
Journal
International Journal of Cancer
Author(s)
Losi  L., Ponz de  L. M., Jiricny  J., Di  G. C., Benatti  P., Percesepe  A., Fante  R., Roncucci  L., Pedroni  M., Benhattar  J.
ISSN
0020-7136 (Print)
Publication state
Published
Issued date
1997
Volume
74
Number
1
Pages
94-96
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't
Abstract
Genetic instability related to defective DNA mismatch repair genes may be involved in the pathogenesis of carcinoma in Hereditary Non-Polyposis Colorectal Cancer (HNPCC). To test that the targets of genetic instability could include critical transforming genes involved in colon tumor progression, we examined 23 colorectal carcinomas in patients with HNPCC in order to detect somatic mutations in K-ras and p53 genes. Using single strand conformation polymorphism followed by direct DNA sequencing, we detected 4 mutations in K-ras gene (17%) and 3 in p53 gene (13%) which change the amino acid sequence of the protein p53. This is significantly lower than in sporadic cancer. Our data suggest that colon cancer in HNPCC might partly involve a distinct pathogenetic mechanism that involves other genes than those altered in sporadic tumors
Keywords
Adult/Aged/Colorectal Neoplasms,Hereditary Nonpolyposis/genetics/mortality/Pathology/DNA Primers/Female/Genes,p53/Genes,ras/Humans/Male/Middle Aged/Mutation/Neoplasm Staging/Polymorphism,Single-Stranded Conformational/Survival Rate/Tumor Suppressor Protein p53/biosynthesis
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 19:35
Last modification date
20/08/2019 17:19
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