Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.

Details

Serval ID
serval:BIB_F183C2E25CDD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Sensing of invading pathogens by GBPs: At the crossroads between cell-autonomous and innate immunity.
Journal
Journal of leukocyte biology
Author(s)
Santos J.C., Broz P.
ISSN
1938-3673 (Electronic)
ISSN-L
0741-5400
Publication state
Published
Issued date
10/2018
Peer-reviewed
Oui
Volume
104
Number
4
Pages
729-735
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Guanylate-binding proteins (GBPs) are conserved family of IFN-inducible GTPases that play an important role in the host immunity against bacterial, viral, and protozoan pathogens. GBPs protect the host by associating with intracellular microbes, their vacuolar niche or, in the case of viruses, with their replication complex. This association results in a restriction of the respective pathogen, yet the exact molecular mechanisms of the antimicrobial functions of GBPs are still unclear. Recent work has linked the GBPs with the activation of inflammasomes, multi-protein complexes that assemble upon recognition of pathogen- or host-derived signals and that drive the release of cytokines and host cell death. Here, we will focus on the most recent findings that have started to unravel the manifold restriction mechanism controlled by GBPs in mouse and human cells, and that shed light on the molecular cues that control GBP recruitment to bacterial membranes.
Keywords
Animals, Bacterial Infections/enzymology, Bacterial Infections/immunology, Caspases/physiology, Cell Membrane/metabolism, Cytokines/metabolism, GTP-Binding Proteins/physiology, Humans, Immunity, Innate, Infection/enzymology, Infection/immunology, Inflammasomes/immunology, Lipopolysaccharides/metabolism, Mammals/immunology, Mice, Parasitic Diseases/enzymology, Parasitic Diseases/immunology, Protein Transport, Protozoan Infections/enzymology, Protozoan Infections/immunology, Virus Diseases/enzymology, Virus Diseases/immunology, Guanylate-binding proteins, caspase-11, inflammasomes, intracellular pathogens
Pubmed
Web of science
Create date
06/08/2018 16:08
Last modification date
20/08/2019 16:19
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