Radiosurgical pathology of brain tumors: metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas.

Details

Serval ID
serval:BIB_F0FE193A3718
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Radiosurgical pathology of brain tumors: metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas.
Journal
Progress in Neurological Surgery
Author(s)
Szeifert G.T., Kondziolka D., Atteberry D.S., Salmon I., Rorive S., Levivier M., Lunsford L.D.
ISSN
0079-6492
Publication state
Published
Issued date
2007
Volume
20
Pages
91-105
Language
english
Notes
Publication types: Journal Article ; Multicenter Study
Abstract
Systematic human pathological background to brain tumor radiosurgery explaining biological and pathophysiological effects of focused irradiation barely exists. The goal of this study was to explore histopathological changes evoked by single high-dose irradiation in a set of different brain tumors following Gamma Knife radiosurgery (GKRS). Light microscopy revealed that GKRS evokes degenerative and proliferative pathological changes in the parenchyma, stroma and vessels of the irradiated tumors. Three main histological types of gamma radiolesions, that is acute, subacute and chronic variants of tissue reactions were recognized in different neoplasms irrespective of their ontogenetic nature. Acute type gamma radiolesions were characterized mainly with necrotic changes and appeared either early or in a delayed time interval. Subacute type gamma radiolesions expressed resorptive activity also with early or delayed chronology. Chronic type lesions showed a reparative tendency but presented only at the delayed stage. These changes seem to follow each other consecutively. There was no significant relation between morphological characteristics of the generated tissue reaction and the time interval elapsed after GKRS. This relative time and environment autonomy of the developed pathological lesions with similar histological picture in different neoplasms suggests either a vascular mechanism or/and a genetically directed origin presumably induced by the ionizing energy of high-dose irradiation.
Keywords
Astrocytoma/pathology, Astrocytoma/surgery, Brain Neoplasms/pathology, Brain Neoplasms/secondary, Hemangioblastoma/pathology, Hemangioblastoma/surgery, Humans, Meningioma/pathology, Meningioma/surgery, Neurilemmoma/pathology, Neurilemmoma/surgery, Radiosurgery/methods, Radiotherapy Dosage, Retrospective Studies, Treatment Outcome
Pubmed
Create date
20/01/2008 18:35
Last modification date
20/08/2019 17:18
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