Radiosurgical pathology of brain tumors: metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas.

Détails

ID Serval
serval:BIB_F0FE193A3718
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Radiosurgical pathology of brain tumors: metastases, schwannomas, meningiomas, astrocytomas, hemangioblastomas.
Périodique
Progress in Neurological Surgery
Auteur(s)
Szeifert G.T., Kondziolka D., Atteberry D.S., Salmon I., Rorive S., Levivier M., Lunsford L.D.
ISSN
0079-6492
Statut éditorial
Publié
Date de publication
2007
Volume
20
Pages
91-105
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Résumé
Systematic human pathological background to brain tumor radiosurgery explaining biological and pathophysiological effects of focused irradiation barely exists. The goal of this study was to explore histopathological changes evoked by single high-dose irradiation in a set of different brain tumors following Gamma Knife radiosurgery (GKRS). Light microscopy revealed that GKRS evokes degenerative and proliferative pathological changes in the parenchyma, stroma and vessels of the irradiated tumors. Three main histological types of gamma radiolesions, that is acute, subacute and chronic variants of tissue reactions were recognized in different neoplasms irrespective of their ontogenetic nature. Acute type gamma radiolesions were characterized mainly with necrotic changes and appeared either early or in a delayed time interval. Subacute type gamma radiolesions expressed resorptive activity also with early or delayed chronology. Chronic type lesions showed a reparative tendency but presented only at the delayed stage. These changes seem to follow each other consecutively. There was no significant relation between morphological characteristics of the generated tissue reaction and the time interval elapsed after GKRS. This relative time and environment autonomy of the developed pathological lesions with similar histological picture in different neoplasms suggests either a vascular mechanism or/and a genetically directed origin presumably induced by the ionizing energy of high-dose irradiation.
Mots-clé
Astrocytoma/pathology, Astrocytoma/surgery, Brain Neoplasms/pathology, Brain Neoplasms/secondary, Hemangioblastoma/pathology, Hemangioblastoma/surgery, Humans, Meningioma/pathology, Meningioma/surgery, Neurilemmoma/pathology, Neurilemmoma/surgery, Radiosurgery/methods, Radiotherapy Dosage, Retrospective Studies, Treatment Outcome
Pubmed
Création de la notice
20/01/2008 18:35
Dernière modification de la notice
03/03/2018 22:37
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