Performance du frottis nasopharyngé-PCR pour le diagnostic du Covid-19 - Recommandations pratiques sur la base des premières données scientifiques [Covid-19 diagnosis : clinical recommendations and performance of nasopharyngeal swab-PCR]

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_F0C317F7B520
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Performance du frottis nasopharyngé-PCR pour le diagnostic du Covid-19 - Recommandations pratiques sur la base des premières données scientifiques [Covid-19 diagnosis : clinical recommendations and performance of nasopharyngeal swab-PCR]
Journal
Revue medicale suisse
Author(s)
Kokkinakis I., Selby K., Favrat B., Genton B., Cornuz J.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
08/04/2020
Peer-reviewed
Oui
Volume
16
Number
689
Pages
699-701
Language
french
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
The Covid-19 pandemic imposes new diagnostic strategies in order to optimize the medical care of our patients. The current biblio-graphy, although of low quality, shows a sensitivity of 56 to 83 % for the Covid-19 PCR. Even though one negative test can exclude a Covid-19 in the majority of cases, the NPV (Negative Predictive Value) decreases with increasing prevalence (pre-test probability). This finding suggests the need for strict auto-isolation of patients until the resolution of their symptoms. For patients that present with typical symptoms, who have a presumed Covid-19 prevalence of -40-50 %, a negative test should be interpreted with caution and a repeat test may be needed.
Keywords
Betacoronavirus/isolation & purification, Coronavirus Infections/diagnosis, Humans, Pandemics, Pneumonia, Viral/diagnosis, Polymerase Chain Reaction/methods, Polymerase Chain Reaction/standards, Predictive Value of Tests, Sensitivity and Specificity
Pubmed
Create date
14/04/2020 11:37
Last modification date
18/06/2020 6:26
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