Patients' sibling history was sensitive for hypertension and specific for diabetes.

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State: Public
Version: author
Serval ID
serval:BIB_EFD7DD0802C1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Patients' sibling history was sensitive for hypertension and specific for diabetes.
Journal
Journal of clinical epidemiology
Author(s)
Bochud M., Burnier M., Paccaud F., Falconnet C., Mooser V., Both N., Bovet P.
ISSN
0895-4356
ISSN-L
0895-4356
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
57
Number
5
Pages
497-501
Language
english
Abstract
OBJECTIVE: We examined the analytic validity of reported family history of hypertension and diabetes among siblings in the Seychelles. STUDY DESIGN AND SETTING: Four hundred four siblings from 73 families with at least two hypertensive persons were identified through a national hypertension register. Two gold standards were used prospectively. Sensitivity was the proportion of respondents who indicated the presence of disease in a sibling, given that the sibling reported to be affected (personal history gold standard) or was clinically affected (clinical status gold standard). Specificity was the proportion of respondents who reported an unaffected sibling, given that the sibling reported to be unaffected or was clinically unaffected. Respondents gave information on the disease status in their siblings in approximately two-thirds of instances. RESULTS: When sibling history could be obtained (n=348 for hypertension, n=404 for diabetes), the sensitivity and the specificity of the sibling history were, respectively, 90 and 55% for hypertension, and 61 and 98% for diabetes, using clinical status and, respectively, 89 and 78% for hypertension, and 53 and 98% for diabetes, using personal history. CONCLUSION: The sibling history, when available, is a useful screening test to detect hypertension, but it is less useful to detect diabetes.
Keywords
Adult, Aged, Diabetes Mellitus, Female, Genetic Predisposition to Disease, Humans, Hypertension, Male, Mass Screening, Medical History Taking, Middle Aged, Prospective Studies, Sensitivity and Specificity, Seychelles
Pubmed
Web of science
Create date
14/03/2008 11:20
Last modification date
20/08/2019 17:17
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