Treatment of bone metastases from breast cancer and myeloma with pamidronate
Details
Serval ID
serval:BIB_EF7564D25619
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Treatment of bone metastases from breast cancer and myeloma with pamidronate
Journal
European Journal of Cancer
ISSN
0959-8049 (Print)
Publication state
Published
Issued date
1991
Volume
27
Number
1
Pages
37-41
Notes
Journal Article
Abstract
28 patients with progressing painful bone metastases (18 breast cancer, 9 myeloma and 1 low grade lymphoma) received pamidronate 60 mg by 24 h continuous infusion for at least 2 courses (range 2-12). In patients urinary calcium and hydroxyproline excretion significantly decreased in relation to diminution of bone resorption. 9 of 18 breast cancer patients and 8 of 9 evaluable patients with myeloma had symptomatic improvement. Sclerotic areas of previously lytic lesions appeared in 8 breast cancer patients and in 1 myeloma patient. Transient fever developed in 1 patient and local phlebitis in 2. Among the 28 patients, 15 did not receive any anticancer treatment or have any change of the anticancer therapy during pamidronate administration. Of 7 with breast cancer, 4 had an improvement of symptoms and 4 sclerosis on radiographs. Impressive control of symptoms was the major feature of 8 myeloma patients, but only 1 had radiographic sclerosis.
Keywords
Adult
Aged
Aged, 80 and over
Bone Neoplasms/drug therapy/*secondary
Bone Resorption/drug therapy
Breast Neoplasms/*metabolism
Diphosphonates/*therapeutic use
Drug Evaluation
Female
Humans
Middle Aged
Multiple Myeloma/*metabolism
Pubmed
Web of science
Create date
28/01/2008 9:32
Last modification date
20/08/2019 17:17