Treatment of bone metastases from breast cancer and myeloma with pamidronate

Détails

ID Serval
serval:BIB_EF7564D25619
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Treatment of bone metastases from breast cancer and myeloma with pamidronate
Périodique
European Journal of Cancer
Auteur⸱e⸱s
Thiebaud  D., Leyvraz  S., von Fliedner  V., Perey  L., Cornu  P., Thiebaud  S., Burckhardt  P.
ISSN
0959-8049 (Print)
Statut éditorial
Publié
Date de publication
1991
Volume
27
Numéro
1
Pages
37-41
Notes
Journal Article
Résumé
28 patients with progressing painful bone metastases (18 breast cancer, 9 myeloma and 1 low grade lymphoma) received pamidronate 60 mg by 24 h continuous infusion for at least 2 courses (range 2-12). In patients urinary calcium and hydroxyproline excretion significantly decreased in relation to diminution of bone resorption. 9 of 18 breast cancer patients and 8 of 9 evaluable patients with myeloma had symptomatic improvement. Sclerotic areas of previously lytic lesions appeared in 8 breast cancer patients and in 1 myeloma patient. Transient fever developed in 1 patient and local phlebitis in 2. Among the 28 patients, 15 did not receive any anticancer treatment or have any change of the anticancer therapy during pamidronate administration. Of 7 with breast cancer, 4 had an improvement of symptoms and 4 sclerosis on radiographs. Impressive control of symptoms was the major feature of 8 myeloma patients, but only 1 had radiographic sclerosis.
Mots-clé
Adult Aged Aged, 80 and over Bone Neoplasms/drug therapy/*secondary Bone Resorption/drug therapy Breast Neoplasms/*metabolism Diphosphonates/*therapeutic use Drug Evaluation Female Humans Middle Aged Multiple Myeloma/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 8:32
Dernière modification de la notice
20/08/2019 16:17
Données d'usage