Treatment of bone metastases from breast cancer and myeloma with pamidronate
Détails
ID Serval
serval:BIB_EF7564D25619
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Treatment of bone metastases from breast cancer and myeloma with pamidronate
Périodique
European Journal of Cancer
ISSN
0959-8049 (Print)
Statut éditorial
Publié
Date de publication
1991
Volume
27
Numéro
1
Pages
37-41
Notes
Journal Article
Résumé
28 patients with progressing painful bone metastases (18 breast cancer, 9 myeloma and 1 low grade lymphoma) received pamidronate 60 mg by 24 h continuous infusion for at least 2 courses (range 2-12). In patients urinary calcium and hydroxyproline excretion significantly decreased in relation to diminution of bone resorption. 9 of 18 breast cancer patients and 8 of 9 evaluable patients with myeloma had symptomatic improvement. Sclerotic areas of previously lytic lesions appeared in 8 breast cancer patients and in 1 myeloma patient. Transient fever developed in 1 patient and local phlebitis in 2. Among the 28 patients, 15 did not receive any anticancer treatment or have any change of the anticancer therapy during pamidronate administration. Of 7 with breast cancer, 4 had an improvement of symptoms and 4 sclerosis on radiographs. Impressive control of symptoms was the major feature of 8 myeloma patients, but only 1 had radiographic sclerosis.
Mots-clé
Adult
Aged
Aged, 80 and over
Bone Neoplasms/drug therapy/*secondary
Bone Resorption/drug therapy
Breast Neoplasms/*metabolism
Diphosphonates/*therapeutic use
Drug Evaluation
Female
Humans
Middle Aged
Multiple Myeloma/*metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 8:32
Dernière modification de la notice
20/08/2019 16:17