Detection in urine of 4-methyl-2-hexaneamine, a doping agent.

Details

Serval ID
serval:BIB_EF71E19CF71C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Detection in urine of 4-methyl-2-hexaneamine, a doping agent.
Journal
Journal of Chromatography. B
Author(s)
Perrenoud L., Saugy M., Saudan C.
ISSN
1570-0232
Publication state
Published
Issued date
2009
Volume
877
Number
29
Pages
3767-3770
Language
english
Abstract
Stimulants are banned in-competition for all categories of sports by the World Anti-Doping Agency. A simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay employing electrospray ionisation in positive mode was developed in that work for the quantification in urine specimens of 4-methyl-2-hexaneamine, a primary amine exhibiting sympathomimetic properties. Following a simple pretreatment procedure, the analyte was separated using a gradient mobile phase on reverse phase C8 column. Selected reaction monitoring m/z 116.2-->57.3 was specific for detection of 4-methyl-2-hexaneamine and the assay exhibited a linear dynamic range of 50-700 ng/mL. The validated method has been successfully applied to analyze the target compound in food supplements as well as in urine specimens. The administered drug (40 mg) was detected at the level of 350 ng/mL in the urine up to 4 days.
Keywords
Doping, Stimulant, Mass spectrometry, Liquid chromatography, Gas chromatography
Pubmed
Web of science
Create date
10/11/2009 14:49
Last modification date
20/08/2019 17:17
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