Activation-dependent epitopes in the terminal complement pathway

Details

Serval ID
serval:BIB_EEB2BCAE535D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Activation-dependent epitopes in the terminal complement pathway
Journal
Complement and Inflammation
Author(s)
Mollnes  T. E., Lea  T., Tschopp  J.
ISSN
1012-8204 (Print)
Publication state
Published
Issued date
1989
Volume
6
Number
3
Pages
223-35
Notes
Journal Article
Review
Abstract
Assembly of the terminal complement complex (TCC) during complement activation is associated with considerable antigenic changes in the individual C5, C6, C7, C8 and C9 components. Numerous neoepitopes specific for the TCC are exposed. Similarly, native-restricted epitopes specific for the nonactivated components are concealed in the TCC. The present paper reviews these antigenic changes with special reference to available monoclonal antibodies and their utilization in assays to detect and quantify the TCC. Application of such assays in clinical medicine is discussed. Finally, a recommended terminology for the terminal complement pathway is put forward.
Keywords
Antibodies, Monoclonal *Complement Activation Complement C5/immunology Complement C5b Complement C9/immunology Complement Membrane Attack Complex Complement System Proteins/analysis/*immunology Epitopes/*metabolism Humans Immunohistochemistry
Pubmed
Web of science
Create date
24/01/2008 15:19
Last modification date
20/08/2019 16:16
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