Emerging therapies for gout.

Details

Serval ID
serval:BIB_EEA4E92F1C87
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Emerging therapies for gout.
Journal
Rheumatic Diseases Clinics of North America
Author(s)
Edwards N.L., So A.
ISSN
1558-3163 (Electronic)
ISSN-L
0889-857X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
40
Number
2
Pages
375-387
Language
english
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Abstract
Over the past decade much has been learned about the mechanisms of crystal-induced inflammation and renal excretion of uric acid, which has led to more specific targeting of gout therapies and a more potent approach to future management of gout. This article outlines agents being developed for more aggressive lowering of urate and more specific anti-inflammatory activity. The emerging urate-lowering therapies include lesinurad, arhalofenate, ulodesine, and levotofisopam. Novel gout-specific anti-inflammatories include the interleukin-1β inhibitors anakinra, canakinumab, and rilonacept, the melanocortins, and caspase inhibitors. The historic shortcomings of current gout treatment may, in part, be overcome by these novel approaches.
Keywords
Acetamides/therapeutic use, Adrenocorticotropic Hormone/therapeutic use, Antibodies, Monoclonal/therapeutic use, Antirheumatic Agents/therapeutic use, Benzodiazepines/therapeutic use, Gout/drug therapy, Gout Suppressants/therapeutic use, Humans, Imino Furanoses/therapeutic use, Interleukin 1 Receptor Antagonist Protein/therapeutic use, Interleukin-1beta/antagonists & inhibitors, Melanocortins/therapeutic use, Phenylacetates/therapeutic use, Polyethylene Glycols, Pyrimidinones/therapeutic use, Recombinant Fusion Proteins/therapeutic use, Thiazoles, Thioglycolates/therapeutic use, Triazoles/therapeutic use, Urate Oxidase, Uricosuric Agents/therapeutic use
Pubmed
Web of science
Create date
15/01/2015 13:13
Last modification date
20/08/2019 17:16
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