Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET.
Details
Serval ID
serval:BIB_EE99FCA9C02B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET.
Journal
Journal of Neuroscience
ISSN
0270-6474 (Print)
ISSN-L
0270-6474
Publication state
Published
Issued date
1992
Volume
12
Number
7
Pages
2542-2548
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Abstract
The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant right hand during serial positron emission tomography (PET) imaging of relative cerebral blood flow (relCBF). The effect of motor execution, rather than learning, was identified by a comparison of four motor performance scans with two control scans (eye movements only). Motor execution was associated with activation of a distributed network involving cortical, striatonigral, and cerebellar sites. Second, the effect of early motor learning was examined. Performance improved from 17% to 66% mean time on target across the four PET scans obtained during pursuit rotor performance. Across the same scans, significant longitudinal increases of relCBF were located in the left primary motor cortex, the left supplementary motor area, and the left pulvinar thalamus. The results demonstrate that changes of regional cerebral activity associated with early learning of skilled movements occur in sites that are a subset of a more widely distributed network that is active during motor execution.
Keywords
Adult, Brain/anatomy & histology, Brain/blood supply, Brain Mapping, Cerebrovascular Circulation, Eye Movements, Female, Functional Laterality, Humans, Learning/physiology, Male, Motor Activity, Movement, Organ Specificity, Regional Blood Flow, Tomography, Emission-Computed/methods
Pubmed
Web of science
Create date
25/09/2011 17:09
Last modification date
20/08/2019 17:16