T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension.

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Serval ID
serval:BIB_EE8EDC0ACBE8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension.
Journal
Nucleic Acids Research
Author(s)
Di Tommaso P., Moretti S., Xenarios I., Orobitg M., Montanyola A., Chang J.M., Taly J.F., Notredame C.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
2011
Volume
39
Number
Web Server issue
Pages
W13-W17
Language
english
Abstract
This article introduces a new interface for T-Coffee, a consistency-based multiple sequence alignment program. This interface provides an easy and intuitive access to the most popular functionality of the package. These include the default T-Coffee mode for protein and nucleic acid sequences, the M-Coffee mode that allows combining the output of any other aligners, and template-based modes of T-Coffee that deliver high accuracy alignments while using structural or homology derived templates. These three available template modes are Expresso for the alignment of protein with a known 3D-Structure, R-Coffee to align RNA sequences with conserved secondary structures and PSI-Coffee to accurately align distantly related sequences using homology extension. The new server benefits from recent improvements of the T-Coffee algorithm and can align up to 150 sequences as long as 10,000 residues and is available from both http://www.tcoffee.org and its main mirror http://tcoffee.crg.cat.
Pubmed
Open Access
Yes
Create date
05/10/2011 11:27
Last modification date
20/08/2019 17:16
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