In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.

Details

Serval ID
serval:BIB_ED849B658265
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Journal
Frontiers in cellular and infection microbiology
Author(s)
Chesnut M., Muñoz L.S., Harris G., Freeman D., Gama L., Pardo C.A., Pamies D.
ISSN
2235-2988 (Electronic)
ISSN-L
2235-2988
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
9
Pages
223
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines. Non-human primates have been used extensively but present major challenges. Advances have also been made toward the development of humanized mouse models, but these models still do not fully represent human pathophysiology. Recent developments in stem cell technology and cell culture techniques have allowed the development of more physiologically relevant human cell-based models. In silico modeling has also allowed researchers to identify and predict transmission patterns and discover potential vaccine and therapeutic candidates. This review summarizes the research on in vitro and in silico models used to study three mosquito-borne flaviviruses that cause neurological disease in humans: West Nile, Dengue, and Zika. We also propose a roadmap for 21st century research on mosquito-borne flavivirus neuropathogenesis, prevention, and treatment.
Keywords
Animals, Antiviral Agents, Computer Simulation, Culicidae/virology, Databases, Factual, Dengue/prevention & control, Disease Models, Animal, Flavivirus, Flavivirus Infections/prevention & control, Flavivirus Infections/therapy, Flavivirus Infections/transmission, Humans, Immune System, In Vitro Techniques/methods, Mice, Mosquito Control, Neuropathology, Vaccination, Viral Vaccines, West Nile Fever/prevention & control, Zika Virus Infection/prevention & control, Dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), flaviviridae, in silico, in vitro, mosquito-borne flavivirus, neuropathogenesis
Pubmed
Web of science
Open Access
Yes
Create date
01/08/2019 13:42
Last modification date
21/02/2020 7:19
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