In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.

Détails

Ressource 1Télécharger: 31338335_BIB_ED849B658265.pdf (1879.03 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_ED849B658265
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment.
Périodique
Frontiers in cellular and infection microbiology
Auteur⸱e⸱s
Chesnut M., Muñoz L.S., Harris G., Freeman D., Gama L., Pardo C.A., Pamies D.
ISSN
2235-2988 (Electronic)
ISSN-L
2235-2988
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
9
Pages
223
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Résumé
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines. Non-human primates have been used extensively but present major challenges. Advances have also been made toward the development of humanized mouse models, but these models still do not fully represent human pathophysiology. Recent developments in stem cell technology and cell culture techniques have allowed the development of more physiologically relevant human cell-based models. In silico modeling has also allowed researchers to identify and predict transmission patterns and discover potential vaccine and therapeutic candidates. This review summarizes the research on in vitro and in silico models used to study three mosquito-borne flaviviruses that cause neurological disease in humans: West Nile, Dengue, and Zika. We also propose a roadmap for 21st century research on mosquito-borne flavivirus neuropathogenesis, prevention, and treatment.
Mots-clé
Animals, Antiviral Agents, Computer Simulation, Culicidae/virology, Databases, Factual, Dengue/prevention & control, Disease Models, Animal, Flavivirus, Flavivirus Infections/prevention & control, Flavivirus Infections/therapy, Flavivirus Infections/transmission, Humans, Immune System, In Vitro Techniques/methods, Mice, Mosquito Control, Neuropathology, Vaccination, Viral Vaccines, West Nile Fever/prevention & control, Zika Virus Infection/prevention & control, Dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), flaviviridae, in silico, in vitro, mosquito-borne flavivirus, neuropathogenesis
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/08/2019 12:42
Dernière modification de la notice
15/01/2021 7:12
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