Basal cell carcinoma - molecular biology and potential new therapies.

Details

Serval ID
serval:BIB_ED4B4A8C7769
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Basal cell carcinoma - molecular biology and potential new therapies.
Journal
Journal of Clinical Investigation
Author(s)
Kasper M., Jaks V., Hohl D., Toftgård R.
ISSN
1558-8238 (Electronic)
ISSN-L
0021-9738
Publication state
Published
Issued date
2012
Volume
122
Number
2
Pages
455-463
Language
english
Abstract
Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. The realization that aberrant activation of Hedgehog signaling is a pathognomonic feature of BCC development has opened the way for exciting progress toward understanding BCC biology and translation of this knowledge to the clinic. Genetic mouse models closely mimicking human BCCs have provided answers about the tumor cell of origin, and inhibition of Hedgehog signaling is emerging as a potentially useful targeted therapy for patients with advanced or multiple BCCs that have hitherto lacked effective treatment.
Pubmed
Web of science
Open Access
Yes
Create date
02/03/2012 14:49
Last modification date
20/08/2019 16:15
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