Basal cell carcinoma - molecular biology and potential new therapies.

Détails

ID Serval
serval:BIB_ED4B4A8C7769
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Basal cell carcinoma - molecular biology and potential new therapies.
Périodique
Journal of Clinical Investigation
Auteur⸱e⸱s
Kasper M., Jaks V., Hohl D., Toftgård R.
ISSN
1558-8238 (Electronic)
ISSN-L
0021-9738
Statut éditorial
Publié
Date de publication
2012
Volume
122
Numéro
2
Pages
455-463
Langue
anglais
Résumé
Basal cell carcinoma (BCC) of the skin, the most common malignancy in individuals of mixed European descent, is increasing in incidence due to an aging population and sun exposure habits. The realization that aberrant activation of Hedgehog signaling is a pathognomonic feature of BCC development has opened the way for exciting progress toward understanding BCC biology and translation of this knowledge to the clinic. Genetic mouse models closely mimicking human BCCs have provided answers about the tumor cell of origin, and inhibition of Hedgehog signaling is emerging as a potentially useful targeted therapy for patients with advanced or multiple BCCs that have hitherto lacked effective treatment.
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/03/2012 15:49
Dernière modification de la notice
20/08/2019 17:15
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