A qualitative continuous model of cellular auxin and brassinosteroid signaling and their crosstalk.

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Serval ID
serval:BIB_EC715645E193
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A qualitative continuous model of cellular auxin and brassinosteroid signaling and their crosstalk.
Journal
Bioinformatics
Author(s)
Sankar M., Osmont K.S., Rolcik J., Gujas B., Tarkowska D., Strnad M., Xenarios I., Hardtke C.S.
ISSN
1367-4811 (Electronic)
ISSN-L
1367-4803
Publication state
Published
Issued date
2011
Volume
27
Number
10
Pages
1404-1412
Language
english
Abstract
Motivation: Hormone pathway interactions are crucial in shaping plant development, such as synergism between the auxin and brassinosteroid pathways in cell elongation. Both hormone pathways have been characterized in detail, revealing several feedback loops. The complexity of this network, combined with a shortage of kinetic data, renders its quantitative analysis virtually impossible at present.Results: As a first step towards overcoming these obstacles, we analyzed the network using a Boolean logic approach to build models of auxin and brassinosteroid signaling, and their interaction. To compare these discrete dynamic models across conditions, we transformed them into qualitative continuous systems, which predict network component states more accurately and can accommodate kinetic data as they become available. To this end, we developed an extension for the SQUAD software, allowing semi-quantitative analysis of network states. Contrasting the developmental output depending on cell type-specific modulators enabled us to identify a most parsimonious model, which explains initially paradoxical mutant phenotypes and revealed a novel physiological feature.
Keywords
Arabidopsis/metabolism, Cell Growth Processes, Indoleacetic Acids/metabolism, Models, Biological, Plant Growth Regulators/metabolism, Signal Transduction
Pubmed
Web of science
Open Access
Yes
Create date
09/02/2012 16:31
Last modification date
25/09/2019 7:11
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