Comparison of the organization and fine structure of a chicken and a Xenopus laevis vitellogenin gene.

Details

Serval ID
serval:BIB_EBD38594A891
Type
Article: article from journal or magazin.
Collection
Publications
Title
Comparison of the organization and fine structure of a chicken and a Xenopus laevis vitellogenin gene.
Journal
Journal of Biological Chemistry
Author(s)
Nardelli D., van het Schip F.D., Gerber-Huber S., Haefliger J.A., Gruber M., Ab G., Wahli W.
ISSN
0021-9258[print], 0021-9258[linking]
Publication state
Published
Issued date
1987
Volume
262
Number
32
Pages
15377-15385
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The structural organization and the coding nucleotide sequence of the Xenopus laevis A2 and the chicken major vitellogenin genes have been compared. Both genes show the same exon-intron organization. However, the degree of homology between the nucleotide and derived amino acid sequences varies extensively along the genes. Several of the 35 exons are quite similar, and a unique cysteine motif in the lipovitellin II domain is conserved between the two genes. In contrast, one internal region is quite divergent. Part of this region encodes phosvitin, which appears to have evolved rapidly by both point mutations and duplications of serines or short other amino acid stretches. On the basis of these observations, we discuss the possible mechanism of evolution of phosvitin in vertebrates.
Keywords
Amino Acid Sequence, Animals, Base Sequence, Chickens, Molecular Sequence Data, Mutation, Phosvitin/genetics, Vitellogenins/genetics, Xenopus laevis
Pubmed
Web of science
Create date
24/01/2008 17:04
Last modification date
20/08/2019 17:14
Usage data