Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma.

Details

Serval ID
serval:BIB_EB2A4AA7432E
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma.
Journal
Human Pathology
Author(s)
Capella C., Marando A., Longhi E., Bernasconi B., Finzi G., Parravicini C., Sessa F., La Rosa S.
ISSN
1532-8392 (Electronic)
ISSN-L
0046-8177
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
45
Number
6
Pages
1310-1314
Language
english
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Abstract
Merkel cell carcinoma (MCC) is a skin cancer that can also rarely arise in extracutaneous sites including mucosal surfaces. About 80% of MCCs harbor the Merkel cell polyomavirus (MCPyV). All cases of gastric MCCs so far reported were metastases from cutaneous sources. In the present article, we describe for the first time a primary gastric MCC harboring MCPyV. A 72-year-old man presented to clinical observation due to epigastric pain. Upper endoscopy revealed an ulcerated gastric tumor. The patient underwent total gastrectomy. The tumor was composed of mitotically active monomorphic small cells showing round nuclei with finely dispersed chromatin arranged in sheets and nests with large areas of necrosis. Tumor cells were positive for neuroendocrine markers and showed paranuclear dot immunoreactivity for cytokeratin 20. MCPyV was demonstrated with immunohistochemistry and electron microscopy, which showed intranuclear and intracytoplasmic viral particles. The MCPyV DNA in tumor cells was demonstrated with polymerase chain reaction analysis.
Keywords
Aged, Carcinoma, Merkel Cell/pathology, Carcinoma, Merkel Cell/virology, Carcinoma, Neuroendocrine, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Male, Merkel cell polyomavirus, Multiplex Polymerase Chain Reaction, Neoplasm Grading, Polyomavirus Infections/pathology, Polyomavirus Infections/virology, Stomach Neoplasms/pathology, Stomach Neoplasms/virology, Tumor Virus Infections/pathology, Tumor Virus Infections/virology
Pubmed
Web of science
Create date
06/09/2016 11:58
Last modification date
20/08/2019 16:13
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