Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma.

Détails

ID Serval
serval:BIB_EB2A4AA7432E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Primary gastric Merkel cell carcinoma harboring DNA polyomavirus: first description of an unusual high-grade neuroendocrine carcinoma.
Périodique
Human Pathology
Auteur(s)
Capella C., Marando A., Longhi E., Bernasconi B., Finzi G., Parravicini C., Sessa F., La Rosa S.
ISSN
1532-8392 (Electronic)
ISSN-L
0046-8177
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
45
Numéro
6
Pages
1310-1314
Langue
anglais
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Résumé
Merkel cell carcinoma (MCC) is a skin cancer that can also rarely arise in extracutaneous sites including mucosal surfaces. About 80% of MCCs harbor the Merkel cell polyomavirus (MCPyV). All cases of gastric MCCs so far reported were metastases from cutaneous sources. In the present article, we describe for the first time a primary gastric MCC harboring MCPyV. A 72-year-old man presented to clinical observation due to epigastric pain. Upper endoscopy revealed an ulcerated gastric tumor. The patient underwent total gastrectomy. The tumor was composed of mitotically active monomorphic small cells showing round nuclei with finely dispersed chromatin arranged in sheets and nests with large areas of necrosis. Tumor cells were positive for neuroendocrine markers and showed paranuclear dot immunoreactivity for cytokeratin 20. MCPyV was demonstrated with immunohistochemistry and electron microscopy, which showed intranuclear and intracytoplasmic viral particles. The MCPyV DNA in tumor cells was demonstrated with polymerase chain reaction analysis.
Mots-clé
Aged, Carcinoma, Merkel Cell/pathology, Carcinoma, Merkel Cell/virology, Carcinoma, Neuroendocrine, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Male, Merkel cell polyomavirus, Multiplex Polymerase Chain Reaction, Neoplasm Grading, Polyomavirus Infections/pathology, Polyomavirus Infections/virology, Stomach Neoplasms/pathology, Stomach Neoplasms/virology, Tumor Virus Infections/pathology, Tumor Virus Infections/virology
Pubmed
Web of science
Création de la notice
06/09/2016 11:58
Dernière modification de la notice
20/08/2019 16:13
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